Early Influences on Mammary Gland Development, with Suzanne Fenton
نویسندگان
چکیده
منابع مشابه
Mammary Gland Involution: Events, Regulation and Influences on Breast Disease
Lactation is under homeostatic control, and sustained milk stasis or weaning leads to mammary gland involution. This transition is under the control of systemic and local factors. Of all the phases of mammary gland development, involution is the least well understood. Recent epidemiological observations suggest that involution events promote breast diseases, including breast cancer. This has re...
متن کاملMammary gland development and cancer.
The mammary gland is a complex organ that begins development early in gestation and constantly changes in size, shape and function from the time of puberty to menopause. The earliest stages of embryogenesis appear to be independent of steroid hormones, whereas after the 15th week breast structure is largely influenced by a variety of hormones. In most females, further breast development begins ...
متن کاملStromal effects on mammary gland development and breast cancer.
Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here ...
متن کاملA Ror recruit to mammary gland development
All signaling pathways have their complexities , but Wnt signaling may be more complex than most. There are 19 different Wnt ligands in mammals that bind to multiple types of receptors, some of which activate a canonical pathway that stabilizes the tran-scriptional coactivator -catenin, and some of which signal via noncanonical, -catenin– independent pathways. Roarty et al. begin to unpick th...
متن کاملChanges in lipogenesis during mammary-gland development.
The mammary gland is an excellent system with which to study differentiation. During pregnancy, differentiation can be monitored by measuring the biochemical changes that lead to the unique ability of the lobulo-alveolar tissue to synthesize milk components such as milk fat. Unlike most mammalian tissues, the lactating mammary gland of many species synthesizes medium-chain (C, : o-Clz : o ) fat...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2011
ISSN: 0091-6765
DOI: 10.1289/ehp.trp100111